J.M. Rubin-Preminger
Variable temperature studies of a polymorphic system comprising two pairs of enantiotropically related forms: S,S -ethambutol dihydrochloride
Rubin-Preminger, J.M.; Bernstein, J.; Harris, R.K.; Evans, I.R.; Ghi, P.Y.
Authors
Abstract
Of the four known polymorphs of [S,S] -ethambutol dihydrochloride, two transform in an enantiotropic single-crystal-to-single-crystaI phase transformation from Form II to Form I on heating. The crystal structures of these two forms have been solved and compared. Because the other two forms are metastable and are only obtained from the melt, single-crystal data could not be obtained on them. However, all four forms have been characterized, and their relative thermodynamic relationships have been investigated by variable-temperature solid-state C-13 NMR, variable-temperature powder X-ray diffraction studies, differential scanning calorimetry, and optical microscopy.
Citation
Rubin-Preminger, J., Bernstein, J., Harris, R., Evans, I., & Ghi, P. (2004). Variable temperature studies of a polymorphic system comprising two pairs of enantiotropically related forms: S,S -ethambutol dihydrochloride. Crystal Growth and Design, 4(3), 431-439. https://doi.org/10.1021/cg0341959
Journal Article Type | Article |
---|---|
Publication Date | 2004-05 |
Journal | Crystal Growth and Design |
Print ISSN | 1528-7483 |
Electronic ISSN | 1528-7505 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Issue | 3 |
Pages | 431-439 |
DOI | https://doi.org/10.1021/cg0341959 |
Public URL | https://durham-repository.worktribe.com/output/1592844 |
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