Variable temperature studies of a polymorphic system comprising two pairs of enantiotropically related forms: S,S -ethambutol dihydrochloride

Rubin-Preminger, J.M.; Bernstein, J.; Harris, R.K.; Evans, I.R.; Ghi, P.Y.

Abstract

Of the four known polymorphs of [S,S] -ethambutol dihydrochloride, two transform in an enantiotropic single-crystal-to-single-crystaI phase transformation from Form II to Form I on heating. The crystal structures of these two forms have been solved and compared. Because the other two forms are metastable and are only obtained from the melt, single-crystal data could not be obtained on them. However, all four forms have been characterized, and their relative thermodynamic relationships have been investigated by variable-temperature solid-state C-13 NMR, variable-temperature powder X-ray diffraction studies, differential scanning calorimetry, and optical microscopy.

Citation

Rubin-Preminger, J., Bernstein, J., Harris, R., Evans, I., & Ghi, P. (2004). Variable temperature studies of a polymorphic system comprising two pairs of enantiotropically related forms: S,S -ethambutol dihydrochloride. Crystal Growth and Design, 4(3), 431-439. https://doi.org/10.1021/cg0341959

• Journal Article Type: Article
• Publication Date: 2004-05
• Journal: Crystal Growth and Design
• Print ISSN: 1528-7483
• Electronic ISSN: 1528-7505
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 3
• Pages: 431-439
• DOI: https://doi.org/10.1021/cg0341959