Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions.

Liotta, L.A.; Medina, I.; Robinson, J.L.; Carroll, C.L.; Pan, P.-S.; Corral, R.; Cook, K.M.; Johnston, J.V.C.; Curtis, F.A.; Sharples, G.J.; McAlpine, S.R.

Abstract

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions(HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.

Citation

Liotta, L., Medina, I., Robinson, J., Carroll, C., Pan, P., Corral, R., …McAlpine, S. (2004). Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45, 8447-8450. https://doi.org/10.1016/j.tetlet.2004.09.084

• Journal Article Type: Article
• Publication Date: 2004
• Journal: Tetrahedron Letters
• Print ISSN: 0040-4039
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Pages: 8447-8450
• DOI: https://doi.org/10.1016/j.tetlet.2004.09.084
• Keywords: Macrocycles; Peptides; Antibiotics; Holliday junction; Macrocyclic peptides; C-2 symmetrical
• Public URL: https://durham-repository.worktribe.com/output/1591958