Skip to main content

Research Repository

Advanced Search

Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions.

Liotta, L.A.; Medina, I.; Robinson, J.L.; Carroll, C.L.; Pan, P.-S.; Corral, R.; Cook, K.M.; Johnston, J.V.C.; Curtis, F.A.; Sharples, G.J.; McAlpine, S.R.

Authors

L.A. Liotta

I. Medina

J.L. Robinson

C.L. Carroll

P.-S. Pan

R. Corral

K.M. Cook

J.V.C. Johnston

F.A. Curtis

S.R. McAlpine



Abstract

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions(HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.

Citation

Liotta, L., Medina, I., Robinson, J., Carroll, C., Pan, P., Corral, R., …McAlpine, S. (2004). Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45, 8447-8450. https://doi.org/10.1016/j.tetlet.2004.09.084

Journal Article Type Article
Publication Date 2004
Journal Tetrahedron Letters
Print ISSN 0040-4039
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 45
Pages 8447-8450
DOI https://doi.org/10.1016/j.tetlet.2004.09.084
Keywords Macrocycles; Peptides; Antibiotics; Holliday junction; Macrocyclic peptides; C-2 symmetrical