To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions

Arnold, K.; Davies, B.; Giles, R.L.; Grosjean, C.; Smith, G.E.; Whiting, A.

Abstract

Kinetic studies show that the direct formation of amides from amines and carboxylic acids without catalyst does occur under relatively low temperature conditions, but is highly substrate dependent. Boric and boronic acid-based catalysts improve the reaction, especially for less reactive acids, and initial results indicate that bifunctional catalysts show even greater potential.

Citation

Arnold, K., Davies, B., Giles, R., Grosjean, C., Smith, G., & Whiting, A. (2006). To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions. Advanced Synthesis & Catalysis, 348(7-8), 813-820. https://doi.org/10.1002/adsc.200606018

• Journal Article Type: Article
• Publication Date: May 5, 2006
• Deposit Date: Apr 10, 2007
• Journal: Advanced Synthesis & Catalysis
• Print ISSN: 1615-4150
• Electronic ISSN: 1615-4169
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 348
• Issue: 7-8
• Pages: 813-820
• DOI: https://doi.org/10.1002/adsc.200606018
• Keywords: Amines, Bifunctional catalysis, Boronate catalysis, Carboxylic acids, Direct amide formation, Green catalysis.
• Public URL: https://durham-repository.worktribe.com/output/1577248