Professor Andreas Maehle a.h.maehle@durham.ac.uk
Professor
In present-day pharmacology, the existence of specific cell receptors, which can combine chemically with drugs, poisons, neurotransmitters and hormones, is often taken for granted. However, until the 1960s receptors were controversial hypothetical entities. This article examines the initial experimental evidence for receptors that was produced and discussed between the 1870s and the 1930s. It is argued that pharmacologists were reluctant to adopt the receptor concept because of the indirect nature of the available experimental evidence, the competition with a physical theory of drug action and the fact that the idea of receptors had not originated from pharmacology itself, but from immunology and neurophysiology.
Maehle, A. (2004). Historische Grundlagen des Rezeptor-Konzepts in der Pharmakologie *. Gesnerus, 61(1-2), 57-76
Journal Article Type | Article |
---|---|
Publication Date | 2004 |
Deposit Date | Apr 10, 2007 |
Journal | Gesnerus. |
Print ISSN | 0016-9161 |
Electronic ISSN | 2297-7953 |
Publisher | Schwabe AG |
Peer Reviewed | Not Peer Reviewed |
Volume | 61 |
Issue | 1-2 |
Pages | 57-76 |
Keywords | History of pharmacology, Receptors, History of physiology. |
Public URL | https://durham-repository.worktribe.com/output/1576132 |
Publisher URL | http://www.schwabe.ch/docs/magazine/9161-0.html#theme |
A Short History of British Medical Ethics
(2021)
Book
A Dangerous Method? The German Discourse on Hypnotic Suggestion Therapy around 1900
(2017)
Journal Article
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
Apache License Version 2.0 (http://www.apache.org/licenses/)
Apache License Version 2.0 (http://www.apache.org/licenses/)
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search