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Activation of the unfolded protein response and alternative splicing of ATF6α in HLA-B27 positive lymphocytes

Lemin, A.; Saleki, K.; van Lith, M.; Benham, A.M.

Authors

A. Lemin

K. Saleki

M. van Lith



Abstract

Misfolding of major histocompatibility complex (MHC) class I molecules has been implicated in the rheumatic autoimmune disease ankylosing spondylitis (AS), and has been linked to the unfolded protein response (UPR) in rodent AS models. XBP1 and ATF6α are two important transcription factors that initiate and co‐ordinate the UPR. Here we show that misoxidised MHC class I heavy chains activate XBP1 processing in a similar manner to tunicamycin, with tunicamycin and dithiothreitol (DTT) inducing differential XBP1 processing. Unexpectedly, ATF6α mRNA is alternatively spliced during reducing stress in lymphocytes. This shorter ATF6α message lacks exon 7 and may have a regulatory role in the UPR.

Citation

Lemin, A., Saleki, K., van Lith, M., & Benham, A. (2007). Activation of the unfolded protein response and alternative splicing of ATF6α in HLA-B27 positive lymphocytes. FEBS Letters, 581(9), 1819-1824. https://doi.org/10.1016/j.febslet.2007.03.069

Journal Article Type Article
Publication Date 2007-04
Journal FEBS Letters
Print ISSN 0014-5793
Electronic ISSN 1873-3468
Publisher Federation of European Biochemical Societies
Peer Reviewed Peer Reviewed
Volume 581
Issue 9
Pages 1819-1824
DOI https://doi.org/10.1016/j.febslet.2007.03.069