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Mechanistic studies on acyl-transferase ribozymes and beyond

Hodgson, D.R.W.; Suga, H.


H. Suga


In vitro selection has allowed the isolation of many new ribozymes that are able to catalyze an ever-widening array of chemical transformations. Mechanistic studies on these selected ribozymes have provided valuable insight into the methods that RNA can invoke to overcome different catalytic tasks. We focus on the methods employed in these mechanistic studies using the acyl-transferase family of selected ribozymes as well-studied reference systems. Chemical and biochemical techniques have been used in tandem in order to draw conclusions on the various modes of catalysis employed by the different family members. In turn, this type of mechanistic information may provide a means for the redesign and optimization of existing ribozymes or the basis for new selection systems for more powerful RNA catalysts.


Hodgson, D., & Suga, H. (2004). Mechanistic studies on acyl-transferase ribozymes and beyond. Biopolymers, 73(1), 130-150.

Journal Article Type Article
Publication Date Jan 1, 2004
Deposit Date Jan 18, 2008
Journal Biopolymers
Print ISSN 0006-3525
Electronic ISSN 1097-0282
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 73
Issue 1
Pages 130-150