Endoplasmic reticulum stress responses

Schröder, M.

Abstract

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of homeostasis causes stress. In this review I summarize how perturbation of three major functions of the endoplasmic reticulum (ER) in eukaryotic cells-protein folding, lipid and sterol biosynthesis, and storing intracellular Ca2+ - causes ER stress and activates signaling pathways collectively termed the unfolded protein response (UPR). I discuss how the UPR reestablishes homeostasis, and summarize our current understanding of how the transition from protective to apoptotic UPR signaling is controlled, and how the UPR induces inflammatory signaling.

Citation

Schröder, M. (2008). Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences, 65(6), 862-894. https://doi.org/10.1007/s00018-007-7383-5

• Journal Article Type: Article
• Publication Date: 2008-11
• Journal: Cellular and Molecular Life Sciences
• Print ISSN: 1420-682X
• Electronic ISSN: 1420-9071
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 65
• Issue: 6
• Pages: 862-894
• DOI: https://doi.org/10.1007/s00018-007-7383-5
• Public URL: https://durham-repository.worktribe.com/output/1558836
• Publisher URL: http://www.springerlink.com/content/e13335205n87q577/fulltext.pdf