KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope

Schneider, M.; Noegel, A.A.; Karakesisoglou, I.

Abstract

Over the last few years, several novel proteins have been identified that facilitate the physical integration of the nucleus with the cytoplasmic compartment. The majority belong to the evolutionarily conserved KASH [klarsicht/ANC-1 (anchorage 1)/SYNE (synaptic nuclear envelope protein) homology]-domain family, which function primarily as exclusive outer nuclear membrane scaffolds that associate with the cytoskeleton, the centrosome and the motor protein apparatus. In the present paper, we propose a novel model, which may explain why these proteins also determine nuclear architecture. Moreover, we discuss further nuclear membrane-tethering devices, which indicate collectively the presence of specific molecular mechanisms that organize the cytoplasmic-nuclear membrane interface in mammalian cells.

Citation

Schneider, M., Noegel, A., & Karakesisoglou, I. (2008). KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope. Biochemical Society Transactions, 36(Pt 6), 1368-72

• Journal Article Type: Article
• Publication Date: 2008
• Journal: Biochem Soc Trans
• Print ISSN: 0300-5127
• Publisher: Portland Press
• Volume: 36
• Issue: Pt 6
• Pages: 1368-72
• Publisher URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19021557