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Regulation of prokaryotic adenylyl cyclases by CO₂

Hammer, A.; Hodgson, D.R.W.; Cann, M.J.

Regulation of prokaryotic adenylyl cyclases by CO₂ Thumbnail


A. Hammer


The Slr1991 adenylyl cyclase of the model prokaroyte Synechocystis PCC 6803 was stimulated 2-fold at 20 mM total Ci (inorganic carbon) atpH 7.5 through an increase in kcat.Adose response demonstrated an EC50 of 52.7 mMtotal Ci at pH 6.5. Slr1991 adenylyl cyclase was activated by CO2, but not by HCO3−. CO2 regulation of adenylyl cyclase was conserved in the CyaB1 adenylyl cyclase of Anabaena PCC 7120. These adenylyl cyclases represent the only identified signalling enzymes directly activated by CO2. The findings prompt an urgent reassessment of the activating carbon species for proposed HCO3−-activated adenylyl cyclases.


Hammer, A., Hodgson, D., & Cann, M. (2006). Regulation of prokaryotic adenylyl cyclases by CO₂. Biochemical Journal, 396(2), 215-218.

Journal Article Type Article
Publication Date Jan 1, 2006
Deposit Date May 10, 2007
Publicly Available Date Nov 27, 2014
Journal Biochemical Journal
Print ISSN 0264-6021
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 396
Issue 2
Pages 215-218
Keywords Adenylyl cyclase (adenyl cyclase, Adenylate
cyclase), Bicarbonate (HCO3−), cAMP, Carbon dioxide (CO2),
Public URL


Accepted Journal Article (397 Kb)

Copyright Statement
This research was originally published in Biochemical journal. Hammer, A., Hodgson, D. R. W., Cann, M.J., Regulation of prokaryotic adenylyl cyclases by CO2. Biochemical journal. 2006; 396: 215-218 © the Biochemical Society

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