The unfolded protein response

Schröder, M.

Abstract

The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular chaperone and protein foldase expression to increase the protein folding capacity of the ER, induction of phospholipid synthesis, attenuation of general translation, and upregulation of ER associated degradation to decrease the unfolded protein load of the ER, and an antioxidant response. Upon severe or prolonged ER stress the UPR induces apoptosis to eliminate unhealthy cells from an organism or a population. In this review I will summarize our current knowledge about signal transduction pathways involved in transducing the unfolded protein signal from the ER to the nucleus or the cytosol.

Citation

Schröder, M. (2006). The unfolded protein response. Molecular Biotechnology, 34(2), 279-290

• Journal Article Type: Article
• Publication Date: 2006-10
• Journal: Molecular Biotechnology
• Print ISSN: 1073-6085
• Electronic ISSN: 1559-0305
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 2
• Pages: 279-290
• Keywords: unfolded protein response, endoplasmic reticulum, chaperone, apoptosis
• Public URL: https://durham-repository.worktribe.com/output/1546109
• Publisher URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17172673&query_hl=5&itool=pubmed_docsum