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Fertilization: a sperm's journey to and interaction with the oocyte.

Ikawa, M.; Inoue, N.; Benham, A.M.; Okabe, M.

Authors

M. Ikawa

N. Inoue

M. Okabe



Abstract

Mammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Recent gene knockout approaches in mice have revealed that many factors previously considered important for fertilization are largely dispensable, or if they are essential, they have an unexpected function. These results indicate that what has been observed in in vitro fertilization (IVF) differs significantly from what occurs during “physiological” fertilization. This Review focuses on the advantages of studying fertilization using gene-manipulated animals and highlights an emerging molecular mechanism of mammalian fertilization.

Citation

Ikawa, M., Inoue, N., Benham, A., & Okabe, M. (2010). Fertilization: a sperm's journey to and interaction with the oocyte. Journal of Clinical Investigation, 120(4), 984-994. https://doi.org/10.1172/jci41585

Journal Article Type Article
Publication Date 2010-04
Deposit Date May 14, 2010
Journal Journal of Clinical Investigation
Print ISSN 0021-9738
Publisher American Society for Clinical Investigation
Peer Reviewed Peer Reviewed
Volume 120
Issue 4
Pages 984-994.
DOI https://doi.org/10.1172/jci41585