Chiara Gagliardi
Evolution of Neurologic Features in Williams Syndrome
Gagliardi, Chiara; Martelli, Sara; Burt, D. Michael; Borgatti, Renato
Abstract
As a part of a large multidisciplinary clinical and research follow-up study, 47 Williams syndrome patients underwent detailed neurologic testing. Because previous studies have documented the absence of major neurologic signs in Williams syndrome, the neurologic testing focused on soft signs. Previous findings of impairment of both gross and fine motor coordination were confirmed, and the presence of mild cerebellar and extrapyramidal signs was documented. In a 4-year follow-up study, an age-related pattern was revealed: soft extrapyramidal signs became more evident from 8 years of age and increased in the 14 year age group. The results are discussed according to a hypothesis related to the dopaminergic system involvement in Williams syndrome: anomalous organization or accelerated ageing process.
Citation
Gagliardi, C., Martelli, S., Burt, D. M., & Borgatti, R. (2007). Evolution of Neurologic Features in Williams Syndrome. Pediatric Neurology, 36(5), 301-306. https://doi.org/10.1016/j.pediatrneurol.2007.01.001
Journal Article Type | Article |
---|---|
Publication Date | May 1, 2007 |
Deposit Date | Nov 2, 2009 |
Journal | Pediatric Neurology |
Print ISSN | 0887-8994 |
Electronic ISSN | 1873-5150 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 36 |
Issue | 5 |
Pages | 301-306 |
DOI | https://doi.org/10.1016/j.pediatrneurol.2007.01.001 |
Public URL | https://durham-repository.worktribe.com/output/1542778 |
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