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Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

Trmčić, M; Hodgson, DRW

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Authors

M Trmčić



Abstract

An aqueous method for the preparation of N,S-dialkyl thiophosphoramidates is reported. Thiophosphorylation of alkylamines was performed using SPCl3 in aqueous reaction media, and the resulting thiophosphoramidate-S-anions were S-alkylated with soft electrophiles. Ranges of amines and electrophiles were explored.

Citation

Trmčić, M., & Hodgson, D. (2011). Synthesis of thiophosphoramidates in water: Click chemistry for phosphates. Chemical Communications, 47(21), 6156-6158. https://doi.org/10.1039/c1cc11586c

Journal Article Type Article
Publication Date Jun 7, 2011
Deposit Date Feb 6, 2012
Publicly Available Date Nov 6, 2014
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 47
Issue 21
Pages 6156-6158
DOI https://doi.org/10.1039/c1cc11586c
Public URL https://durham-repository.worktribe.com/output/1514762

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