K. Fucke
Unexpected Low Temperature Behaviour of Piroxicam Monohydrate
Fucke, K.; Edwards, A.J.; Probert, M.R.; Tallentire, S.E.; Howard, J.A.K.; Steed, J.W.
Authors
A.J. Edwards
M.R. Probert
S.E. Tallentire
J.A.K. Howard
Professor Jonathan Steed jon.steed@durham.ac.uk
Professor
Abstract
Upon cooling the monohydrate of the anti-inflammatory drug piroxicam shows reversible splitting (see picture). The cell also shows an irregular contraction over temperature and has a memory effect of its thermal history. This is due to strongly hydrogen bonded chains present in the monohydrate, which allow the crystal domains to contract separately from each other.
Citation
Fucke, K., Edwards, A., Probert, M., Tallentire, S., Howard, J., & Steed, J. (2013). Unexpected Low Temperature Behaviour of Piroxicam Monohydrate. ChemPhysChem, 14(4), 675-679. https://doi.org/10.1002/cphc.201200316
| Journal Article Type | Article |
|---|---|
| Publication Date | Mar 18, 2013 |
| Deposit Date | Mar 27, 2013 |
| Publicly Available Date | Mar 27, 2013 |
| Journal | ChemPhysChem |
| Print ISSN | 1439-4235 |
| Electronic ISSN | 1439-7641 |
| Publisher | Wiley |
| Peer Reviewed | Peer Reviewed |
| Volume | 14 |
| Issue | 4 |
| Pages | 675-679 |
| DOI | https://doi.org/10.1002/cphc.201200316 |
| Keywords | Lattice energy calculations, Neutron diffraction, Piroxicam monohydrate, Temperature-controlled analysis, X-ray diffraction. |
| Public URL | https://durham-repository.worktribe.com/output/1490371 |
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Copyright Statement
This is the peer reviewed version of the following article: Fucke, K., Edwards, A. J., Probert, M. R., Tallentire, S. E., Howard, J. A. K. and Steed, J. W. (2013), Unexpected Low-Temperature Behaviour of Piroxicam Monohydrate. ChemPhysChem, 14 (4): 675–679, which has been published in final form at http://dx.doi.org/10.1002/cphc.201200316. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.