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Unexpected Low Temperature Behaviour of Piroxicam Monohydrate

Fucke, K.; Edwards, A.J.; Probert, M.R.; Tallentire, S.E.; Howard, J.A.K.; Steed, J.W.

Unexpected Low Temperature Behaviour of Piroxicam Monohydrate Thumbnail


K. Fucke

A.J. Edwards

M.R. Probert

S.E. Tallentire

J.A.K. Howard


Upon cooling the monohydrate of the anti-inflammatory drug piroxicam shows reversible splitting (see picture). The cell also shows an irregular contraction over temperature and has a memory effect of its thermal history. This is due to strongly hydrogen bonded chains present in the monohydrate, which allow the crystal domains to contract separately from each other.


Fucke, K., Edwards, A., Probert, M., Tallentire, S., Howard, J., & Steed, J. (2013). Unexpected Low Temperature Behaviour of Piroxicam Monohydrate. ChemPhysChem, 14(4), 675-679.

Journal Article Type Article
Publication Date Mar 18, 2013
Deposit Date Mar 27, 2013
Publicly Available Date Mar 27, 2013
Journal ChemPhysChem
Print ISSN 1439-4235
Electronic ISSN 1439-7641
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 14
Issue 4
Pages 675-679
Keywords Lattice energy calculations, Neutron diffraction, Piroxicam monohydrate, Temperature-controlled analysis, X-ray diffraction.


Accepted Journal Article (1.7 Mb)

Copyright Statement
This is the peer reviewed version of the following article: Fucke, K., Edwards, A. J., Probert, M. R., Tallentire, S. E., Howard, J. A. K. and Steed, J. W. (2013), Unexpected Low-Temperature Behaviour of Piroxicam Monohydrate. ChemPhysChem, 14 (4): 675–679, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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