Unexpected Low Temperature Behaviour of Piroxicam Monohydrate

Fucke, K.; Edwards, A.J.; Probert, M.R.; Tallentire, S.E.; Howard, J.A.K.; Steed, J.W.

Abstract

Upon cooling the monohydrate of the anti-inflammatory drug piroxicam shows reversible splitting (see picture). The cell also shows an irregular contraction over temperature and has a memory effect of its thermal history. This is due to strongly hydrogen bonded chains present in the monohydrate, which allow the crystal domains to contract separately from each other.

Citation

Fucke, K., Edwards, A., Probert, M., Tallentire, S., Howard, J., & Steed, J. (2013). Unexpected Low Temperature Behaviour of Piroxicam Monohydrate. ChemPhysChem, 14(4), 675-679. https://doi.org/10.1002/cphc.201200316

• Journal Article Type: Article
• Publication Date: Mar 18, 2013
• Deposit Date: Mar 27, 2013
• Publicly Available Date: Mar 27, 2013
• Journal: ChemPhysChem
• Print ISSN: 1439-4235
• Electronic ISSN: 1439-7641
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 4
• Pages: 675-679
• DOI: https://doi.org/10.1002/cphc.201200316
• Keywords: Lattice energy calculations, Neutron diffraction, Piroxicam monohydrate, Temperature-controlled analysis, X-ray diffraction.
• Public URL: https://durham-repository.worktribe.com/output/1490371