Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice

Taylor, A. M.; Niewoehner, B.; Seeburg, P. H.; Sprengel, R.; Rawlins, J. N. P.; Bannerman, D. M.; Sanderson, D. J.

Abstract

GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.

Citation

Taylor, A. M., Niewoehner, B., Seeburg, P. H., Sprengel, R., Rawlins, J. N. P., Bannerman, D. M., & Sanderson, D. J. (2011). Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice. Behavioural Brain Research, 224(1), 8-14. https://doi.org/10.1016/j.bbr.2011.05.016

• Journal Article Type: Article
• Publication Date: Oct 10, 2011
• Deposit Date: Sep 21, 2012
• Publicly Available Date: Feb 24, 2017
• Journal: Behavioural Brain Research
• Print ISSN: 0166-4328
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 224
• Issue: 1
• Pages: 8-14
• DOI: https://doi.org/10.1016/j.bbr.2011.05.016
• Keywords: AMPA receptors, Conditional learning, Trace conditioning, Non-spatial memory, Spatial memory.
• Public URL: https://durham-repository.worktribe.com/output/1473625