Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9†‡

Ayub, M.; Irfan, M.; Maclean, A.; Naeem, F.; Blackwood, D.

Abstract

A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression.

Citation

Ayub, M., Irfan, M., Maclean, A., Naeem, F., & Blackwood, D. (2013). Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9†‡. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 157-162. https://doi.org/10.1002/ajmg.b.32126

• Journal Article Type: Article
• Publication Date: Mar 1, 2013
• Deposit Date: Jan 7, 2013
• Journal: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
• Print ISSN: 1552-4841
• Electronic ISSN: 1552-485X
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 162
• Issue: 2
• Pages: 157-162
• DOI: https://doi.org/10.1002/ajmg.b.32126
• Keywords: Major depressive disorder, Homozygosity mapping, Pakistan, Genetic linkage.
• Public URL: https://durham-repository.worktribe.com/output/1468013