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Nonparametric predictive inference for diagnostic accuracy

Coolen-Maturi, T.; Coolen-Schrijner, P.; Coolen, F.P.A.


P. Coolen-Schrijner


Measuring the accuracy of diagnostic tests is crucial in many application areas including medicine and health care. Good methods for determining diagnostic accuracy provide useful guidance on selection of patient treatment, and the ability to compare different diagnostic tests has a direct impact on quality of care. In this paper Nonparametric Predictive Inference (NPI) methods for accuracy of diagnostic tests with continuous test results are presented and discussed. For such tests, Receiver Operating Characteristic (ROC) curves have become popular tools for describing the performance of diagnostic tests. We present the NPI approach to ROC curves, and some important summaries of these curves. As NPI does not aim at inference for an entire population but instead explicitly considers a future observation, this provides an attractive alternative to standard methods. We show how NPI can be used to compare two continuous diagnostic tests.


Coolen-Maturi, T., Coolen-Schrijner, P., & Coolen, F. (2012). Nonparametric predictive inference for diagnostic accuracy. Journal of Statistical Planning and Inference, 142(5), 1141-1150.

Journal Article Type Article
Publication Date 2012-05
Deposit Date Mar 29, 2013
Journal Journal of Statistical Planning and Inference
Print ISSN 0378-3758
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 142
Issue 5
Pages 1141-1150
Public URL