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An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

Baumann, Marcus; Baxendale, Ian R.

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Authors

Marcus Baumann



Abstract

This review which is the second in this series summarises the most common synthetic routes as applied to the preparation of many modern pharmaceutical compounds categorised as containing a six-membered heterocyclic ring. The reported examples are based on the top retailing drug molecules combining synthetic information from both scientific journals and the wider patent literature. It is hoped that this compilation, in combination with the previously published review on five-membered rings, will form a comprehensive foundation and reference source for individuals interested in medicinal, synthetic and preparative chemistry.

Citation

Baumann, M., & Baxendale, I. R. (2013). An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles. Beilstein Journal of Organic Chemistry, 9, 2265-2319. https://doi.org/10.3762/bjoc.9.265

Journal Article Type Article
Acceptance Date Oct 9, 2013
Online Publication Date Oct 30, 2013
Publication Date Oct 30, 2013
Deposit Date Jul 14, 2014
Publicly Available Date Jun 1, 2015
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 9
Pages 2265-2319
DOI https://doi.org/10.3762/bjoc.9.265
Keywords Heterocycles, Medicinal chemistry, Pharmaceuticals, Six-membered rings, Synthesis.
Public URL https://durham-repository.worktribe.com/output/1457110

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Published Journal Article (4.3 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2013 Baumann and Baxendale; licensee Beilstein-Institut.This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)





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