An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles

Baumann, Marcus; Baxendale, Ian R.

Abstract

This review which is the second in this series summarises the most common synthetic routes as applied to the preparation of many modern pharmaceutical compounds categorised as containing a six-membered heterocyclic ring. The reported examples are based on the top retailing drug molecules combining synthetic information from both scientific journals and the wider patent literature. It is hoped that this compilation, in combination with the previously published review on five-membered rings, will form a comprehensive foundation and reference source for individuals interested in medicinal, synthetic and preparative chemistry.

Citation

Baumann, M., & Baxendale, I. R. (2013). An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles. Beilstein Journal of Organic Chemistry, 9, 2265-2319. https://doi.org/10.3762/bjoc.9.265

• Journal Article Type: Article
• Acceptance Date: Oct 9, 2013
• Online Publication Date: Oct 30, 2013
• Publication Date: Oct 30, 2013
• Deposit Date: Jul 14, 2014
• Publicly Available Date: Jun 1, 2015
• Journal: Beilstein Journal of Organic Chemistry
• Print ISSN: 1860-5397
• Electronic ISSN: 1860-5397
• Publisher: Beilstein-Institut
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Pages: 2265-2319
• DOI: https://doi.org/10.3762/bjoc.9.265
• Keywords: Heterocycles, Medicinal chemistry, Pharmaceuticals, Six-membered rings, Synthesis.
• Public URL: https://durham-repository.worktribe.com/output/1457110