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Scale-Up of Flow-Assisted Synthesis of C-2-Symmetric Chiral PyBox Ligands

Battilocchio, Claudio; Baumann, Marcus; Baxendale, Ian R.; Biava, Mariangela; Kitching, Matthew O.; Ley, Steven V.; Martin, Rainer E.; Ohnmacht, Stephan A.; Tappin, Nicholas D.C.


Claudio Battilocchio

Marcus Baumann

Mariangela Biava

Steven V. Ley

Rainer E. Martin

Stephan A. Ohnmacht

Nicholas D.C. Tappin


A series of PyBox ligands were prepared from commercially available chelidonic acid by a multistep flow sequence using mesoreactor technology. A chloro group introduced onto the ligand scaffold was subsequently exploited to give amine derivatives ready for immobilization through microencapsulation technologies.

Journal Article Type Article
Online Publication Date Jan 25, 2012
Publication Date 2012-02
Deposit Date Jul 14, 2014
Journal Synthesis : journal of synthetic organic chemistry.
Print ISSN 0039-7881
Electronic ISSN 1437-210X
Publisher Thieme Gruppe
Peer Reviewed Peer Reviewed
Volume 44
Issue 4
Pages 635-647
Public URL