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An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

Baumann, Marcus; Baxendale, Ian R.; Ley, Steven V.; Nikbin, Nikzad

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Authors

Marcus Baumann

Steven V. Ley

Nikzad Nikbin



Abstract

This review presents a comprehensive overview on selected synthetic routes towards commercial drug compounds as published in both journal and patent literature. Owing to the vast number of potential structures, we have concentrated only on those drugs containing five-membered heterocycles and focused principally on the assembly of the heterocyclic core. In order to target the most representative chemical entities the examples discussed have been selected from the top 200 best selling drugs of recent years.

Journal Article Type Article
Acceptance Date Mar 22, 2011
Publication Date Apr 18, 2011
Deposit Date Jul 14, 2014
Publicly Available Date Jun 1, 2015
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 7
Pages 442-495
DOI https://doi.org/10.3762/bjoc.7.57
Keywords Five-membered rings, Heterocycles, Medicinal chemistry, Pharmaceuticals, Synthesis.
Public URL https://durham-repository.worktribe.com/output/1448031

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Published Journal Article (3.8 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2011 Baumann et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic
Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)





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