Solid-state NMR studies of nucleic acid components

Dračínský, Martin; Hodgkinson, Paul

Abstract

Recent applications of solid-state NMR to the characterisation of nucleic acid systems are reviewed. Developments in NMR methodology and DFT-based first-principles calculations have led to the emergence of “NMR crystallography”, where solid-state NMR provides information on local structure and dynamics that complements information on periodic ordering and overall structure provided by traditional diffraction crystallography. The solid-state NMR is shown to provide direct information on hydrogen-bonding arrangements, metal ion interactions and local molecular dynamics that is difficult to obtain by other techniques, including solution-state NMR.

Citation

Dračínský, M., & Hodgkinson, P. (2015). Solid-state NMR studies of nucleic acid components. RSC Advances, 5(16), 12300-12310. https://doi.org/10.1039/c4ra14404j

• Journal Article Type: Article
• Publication Date: Jan 9, 2015
• Deposit Date: Jan 23, 2015
• Publicly Available Date: Jan 30, 2015
• Journal: RSC Advances
• Electronic ISSN: 2046-2069
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 16
• Pages: 12300-12310
• DOI: https://doi.org/10.1039/c4ra14404j
• Public URL: https://durham-repository.worktribe.com/output/1446595