Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Edkins, Robert M.; Hayden, Elliott; Steed, Jonathan W.; Fucke, Katharina

Abstract

Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.

Citation

Edkins, R. M., Hayden, E., Steed, J. W., & Fucke, K. (2015). Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation. Chemical Communications, 51(25), 5314-5317. https://doi.org/10.1039/c4cc10453f

• Journal Article Type: Article
• Acceptance Date: Feb 10, 2015
• Publication Date: Mar 28, 2015
• Deposit Date: Mar 2, 2015
• Publicly Available Date: Mar 9, 2015
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 51
• Issue: 25
• Pages: 5314-5317
• DOI: https://doi.org/10.1039/c4cc10453f
• Public URL: https://durham-repository.worktribe.com/output/1444931