Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations

Alderson-Day, B.; McCarthy-Jones, S.; Fernyhough, C.

Abstract

Resting state networks (RSNs) are thought to reflect the intrinsic functional connectivity of brain regions. Alterations to RSNs have been proposed to underpin various kinds of psychopathology, including the occurrence of auditory verbal hallucinations (AVH). This review outlines the main hypotheses linking AVH and the resting state, and assesses the evidence for alterations to intrinsic connectivity provided by studies of resting fMRI in AVH. The influence of hallucinations during data acquisition, medication confounds, and movement are also considered. Despite a large variety of analytic methods and designs being deployed, it is possible to conclude that resting connectivity in the left temporal lobe in general and left superior temporal gyrus in particular are disrupted in AVH. There is also preliminary evidence of atypical connectivity in the default mode network and its interaction with other RSNs. Recommendations for future research include the adoption of a common analysis protocol to allow for more overlapping datasets and replication of intrinsic functional connectivity alterations.

Citation

Alderson-Day, B., McCarthy-Jones, S., & Fernyhough, C. (2015). Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations. Neuroscience & Biobehavioral Reviews, 55, 78-87. https://doi.org/10.1016/j.neubiorev.2015.04.016

• Journal Article Type: Article
• Acceptance Date: Apr 25, 2015
• Online Publication Date: May 5, 2015
• Publication Date: Aug 1, 2015
• Deposit Date: Apr 26, 2015
• Publicly Available Date: Jun 1, 2015
• Journal: Neuroscience and Biobehavioral Reviews
• Print ISSN: 0149-7634
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 55
• Pages: 78-87
• DOI: https://doi.org/10.1016/j.neubiorev.2015.04.016
• Keywords: Resting state, Default mode network, Voice-hearing, Inner speech, Schizophrenia.
• Public URL: https://durham-repository.worktribe.com/output/1439720