Hippocampal synaptic plasticity, spatial memory and anxiety

Bannerman, D. M.; Sprengel, R.; Sanderson, D. J.; McHugh, S. B.; Rawlins, J. N. P.; Monyer, H.; Seeburg, P. H.

Abstract

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

Citation

Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014). Hippocampal synaptic plasticity, spatial memory and anxiety. Nature Reviews Neuroscience, 15(3), 181-192. https://doi.org/10.1038/nrn3677

• Journal Article Type: Article
• Online Publication Date: Feb 20, 2014
• Publication Date: Mar 1, 2014
• Deposit Date: Feb 20, 2014
• Publicly Available Date: Dec 19, 2014
• Journal: Nature Reviews Neuroscience
• Print ISSN: 1471-003X
• Electronic ISSN: 1471-0048
• Publisher: Nature Research
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Issue: 3
• Pages: 181-192
• DOI: https://doi.org/10.1038/nrn3677
• Public URL: https://durham-repository.worktribe.com/output/1436606