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Multiple TGF-β superfamily signals modulate the adult Drosophila immune response

Clark, R.I.; Woodcock, K.J.; Geissmann, F.; Trouillet, C.; Dionne, M.S.

Multiple TGF-β superfamily signals modulate the adult Drosophila immune response Thumbnail


Authors

K.J. Woodcock

F. Geissmann

C. Trouillet

M.S. Dionne



Abstract

TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals [1]. Drosophila melanogaster is a well-established model for the study of innate immune function [2, 3] and wound healing [4–7]. Here, we explore the role and regulation of two TGF-β superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infection in adult Drosophila. We find that both TGF-β signals exhibit complex regulation in response to wounding and infection, each is expressed in a subset of phagocytes, and each inhibits a specific arm of the immune response. dpp is rapidly activated by wounds and represses the production of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial peptide expression after even a small wound. dawdle, in contrast, is activated by Gram-positive bacterial infection but repressed by Gram-negative infection or wounding; its role is to limit infection-induced melanization. Flies lacking dawdle function exhibit melanization even when uninfected. Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response.

Citation

Clark, R., Woodcock, K., Geissmann, F., Trouillet, C., & Dionne, M. (2011). Multiple TGF-β superfamily signals modulate the adult Drosophila immune response. Current Biology, 21(19), 1672-1677. https://doi.org/10.1016/j.cub.2011.08.048

Journal Article Type Article
Acceptance Date Aug 19, 2011
Online Publication Date Sep 29, 2011
Publication Date Oct 11, 2011
Deposit Date Aug 13, 2015
Publicly Available Date Jun 15, 2018
Journal Current Biology
Print ISSN 0960-9822
Electronic ISSN 1879-0445
Publisher Cell Press
Peer Reviewed Peer Reviewed
Volume 21
Issue 19
Pages 1672-1677
DOI https://doi.org/10.1016/j.cub.2011.08.048
Public URL https://durham-repository.worktribe.com/output/1433883

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