A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component

Baxendale, I.R.

Abstract

The search for novel chemical architectures displaying improved biological properties is a never-ending synthetic challenge. In this context many new test structures are often conceived by selecting and replicating specific design elements from naturally occurring molecules and displaying them in an alternative format by way of a new chemical assembly. Constructing these newly designed compounds can be a timely and expensive process especially when a large quantity of the target material is required for physiochemical and property testing. To permit easier scale-up and safer working practice, many chemical researchers are employing flow chemistry approaches to aid in their synthesis challenges. The preparation of a key spirocyclic lactone using flow-based reaction processing techniques is reported.

Citation

Baxendale, I. (2015). A Short Multi-step Flow Synthesis of a Potential Spirocyclic Fragrance Component. Chemical Engineering & Technology, 38(10), 1713-1716. https://doi.org/10.1002/ceat.201500255

• Journal Article Type: Article
• Acceptance Date: Jul 30, 2015
• Online Publication Date: Sep 10, 2015
• Publication Date: Oct 1, 2015
• Deposit Date: Aug 21, 2015
• Publicly Available Date: Aug 3, 2016
• Journal: Chemical Engineering and Technology
• Print ISSN: 0930-7516
• Electronic ISSN: 1521-4125
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 38
• Issue: 10
• Pages: 1713-1716
• DOI: https://doi.org/10.1002/ceat.201500255
• Keywords: Flow synthesis, Meso reactor, Multi-step, Diels Alder reaction, Baylis Hillman reaction.
• Public URL: https://durham-repository.worktribe.com/output/1433384