Total syntheses of natural products containing spirocarbocycles

Smith, L.K.; Baxendale, I.R.

Abstract

The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring closure which we examine in this review.

Citation

Smith, L., & Baxendale, I. (2015). Total syntheses of natural products containing spirocarbocycles. Organic and Biomolecular Chemistry, 13(39), 9907-9933. https://doi.org/10.1039/c5ob01524c

• Journal Article Type: Article
• Acceptance Date: Sep 1, 2015
• Publication Date: Oct 21, 2015
• Deposit Date: Sep 17, 2015
• Publicly Available Date: Sep 1, 2016
• Journal: Organic and Biomolecular Chemistry
• Print ISSN: 1477-0520
• Electronic ISSN: 1477-0539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 39
• Pages: 9907-9933
• DOI: https://doi.org/10.1039/c5ob01524c
• Public URL: https://durham-repository.worktribe.com/output/1431591