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Total syntheses of natural products containing spirocarbocycles

Smith, L.K.; Baxendale, I.R.

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L.K. Smith


The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring closure which we examine in this review.

Journal Article Type Article
Acceptance Date Sep 1, 2015
Publication Date Oct 21, 2015
Deposit Date Sep 17, 2015
Publicly Available Date Sep 1, 2016
Journal Organic and Biomolecular Chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 13
Issue 39
Pages 9907-9933
Public URL


Accepted Journal Article (2.4 Mb)

Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

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