The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

Baxendale, I.R.; Cheung, S.; Kitching, M.O.; Ley, S.V.; Shearman, J.W.

Abstract

An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.

Citation

Baxendale, I., Cheung, S., Kitching, M., Ley, S., & Shearman, J. (2013). The synthesis of neurotensin antagonist SR 48692 for prostate cancer research. Bioorganic and Medicinal Chemistry, 21(14), 4378-4387. https://doi.org/10.1016/j.bmc.2013.04.075

• Journal Article Type: Article
• Acceptance Date: Apr 20, 2013
• Online Publication Date: May 6, 2013
• Publication Date: 2013-07
• Deposit Date: Jul 14, 2014
• Journal: Bioorganic and Medicinal Chemistry
• Print ISSN: 0968-0896
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 14
• Pages: 4378-4387
• DOI: https://doi.org/10.1016/j.bmc.2013.04.075
• Public URL: https://durham-repository.worktribe.com/output/1426428