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The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

Baxendale, I.R.; Cheung, S.; Kitching, M.O.; Ley, S.V.; Shearman, J.W.


S. Cheung

S.V. Ley

J.W. Shearman


An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.

Journal Article Type Article
Acceptance Date Apr 20, 2013
Online Publication Date May 6, 2013
Publication Date 2013-07
Deposit Date Jul 14, 2014
Journal Bioorganic and Medicinal Chemistry
Print ISSN 0968-0896
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 21
Issue 14
Pages 4378-4387
Public URL