The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction

Bourne, Samuel L.; Koos, Peter; O'Brien, Matthew; Martin, Benjamin; Schenkel, Berthold; Baxendale, Ian R.; Ley, Steven V.

Abstract

We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure.

Citation

Bourne, S. L., Koos, P., O'Brien, M., Martin, B., Schenkel, B., Baxendale, I. R., & Ley, S. V. (2011). The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 2643-2647. https://doi.org/10.1055/s-0031-1289291

• Journal Article Type: Article
• Acceptance Date: Sep 7, 2011
• Online Publication Date: Oct 7, 2011
• Publication Date: 2011-11
• Deposit Date: Jul 14, 2014
• Journal: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
• Print ISSN: 0936-5214
• Electronic ISSN: 1437-2096
• Publisher: Thieme Gruppe
• Peer Reviewed: Peer Reviewed
• Issue: 18
• Pages: 2643-2647
• DOI: https://doi.org/10.1055/s-0031-1289291
• Public URL: https://durham-repository.worktribe.com/output/1426303