A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT(1B) Antagonist

Qian, Zizheng; Baxendale, Ian R.; Ley, Steven V.

Abstract

This article describes the continuous flow synthesis of ­6-methoxy-8-(4-methyl-1,4-diazepan-1-yl)-N-(4-morpholinophen-yl)-4-oxo-1,4-dihydroquinoline-2-carboxamide, a potent 5HT1B antagonist developed by AstraZeneca.

Citation

Qian, Z., Baxendale, I. R., & Ley, S. V. (2010). A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT(1B) Antagonist. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 505-508. https://doi.org/10.1055/s-0029-1219358

• Journal Article Type: Article
• Acceptance Date: Jan 8, 2010
• Online Publication Date: Feb 8, 2010
• Publication Date: 2010-03
• Deposit Date: Jul 14, 2014
• Journal: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
• Print ISSN: 0936-5214
• Electronic ISSN: 1437-2096
• Publisher: Thieme Gruppe
• Peer Reviewed: Peer Reviewed
• Issue: 4
• Pages: 505-508
• DOI: https://doi.org/10.1055/s-0029-1219358
• Public URL: https://durham-repository.worktribe.com/output/1426159