New focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process

Hopkin, Mark D.; Baxendale, Ian R.; Ley, Steven V.

Abstract

A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in their formation represent novel compounds. Focused microwave irradiation was used extensively to allow simple access to a wide temperature range using low boiling point solvents.

Citation

Hopkin, M. D., Baxendale, I. R., & Ley, S. V. (2008). New focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process. Synthesis: Journal of Synthetic Organic Chemistry, 1688-1702. https://doi.org/10.1055/s-2008-1067048

• Journal Article Type: Article
• Acceptance Date: Mar 29, 2008
• Online Publication Date: Apr 29, 2008
• Publication Date: 2008-06
• Deposit Date: Jul 14, 2014
• Journal: Synthesis : journal of synthetic organic chemistry.
• Print ISSN: 0039-7881
• Electronic ISSN: 1437-210X
• Publisher: Thieme Gruppe
• Peer Reviewed: Peer Reviewed
• Issue: 11
• Pages: 1688-1702
• DOI: https://doi.org/10.1055/s-2008-1067048
• Public URL: https://durham-repository.worktribe.com/output/1426081