A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

Baxendale, IR; Deeley, J; Griffiths-Jones, CM; Ley, SV; Saaby, S; Tranmer, GK

Abstract

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.

Citation

Baxendale, I., Deeley, J., Griffiths-Jones, C., Ley, S., Saaby, S., & Tranmer, G. (2006). A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly. Chemical Communications, 2566-2568. https://doi.org/10.1039/b600382f

• Journal Article Type: Article
• Acceptance Date: Feb 3, 2006
• Online Publication Date: Mar 24, 2006
• Publication Date: 2006
• Deposit Date: Jul 14, 2014
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Issue: 24
• Pages: 2566-2568
• DOI: https://doi.org/10.1039/b600382f
• Public URL: https://durham-repository.worktribe.com/output/1425988