Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Nakayama, Keiji; Browne, Duncan L.; Baxendale, Ian R.; Ley, Steven V.

Abstract

The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables.

Citation

Nakayama, K., Browne, D. L., Baxendale, I. R., & Ley, S. V. (2013). Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor. Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 24(10), 1298-1302. https://doi.org/10.1055/s-0033-1338455

• Journal Article Type: Article
• Publication Date: 2013-06
• Deposit Date: Jul 14, 2014
• Journal: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
• Print ISSN: 0936-5214
• Electronic ISSN: 1437-2096
• Publisher: Thieme Gruppe
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 10
• Pages: 1298-1302
• DOI: https://doi.org/10.1055/s-0033-1338455
• Public URL: https://durham-repository.worktribe.com/output/1423789