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Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Nakayama, Keiji; Browne, Duncan L.; Baxendale, Ian R.; Ley, Steven V.

Authors

Keiji Nakayama

Duncan L. Browne

Steven V. Ley



Abstract

The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables.

Journal Article Type Article
Publication Date 2013-06
Deposit Date Jul 14, 2014
Journal Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry
Print ISSN 0936-5214
Electronic ISSN 1437-2096
Publisher Thieme Gruppe
Peer Reviewed Peer Reviewed
Volume 24
Issue 10
Pages 1298-1302
DOI https://doi.org/10.1055/s-0033-1338455
Public URL https://durham-repository.worktribe.com/output/1423789