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Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Baumann, M.; Baxendale, I.R.; Hornung, C.H.; Ley, S.V.; Rojo, M.V.; Roper, K.A.

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations Thumbnail


Authors

M. Baumann

C.H. Hornung

S.V. Ley

M.V. Rojo

K.A. Roper



Abstract

Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.

Citation

Baumann, M., Baxendale, I., Hornung, C., Ley, S., Rojo, M., & Roper, K. (2014). Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations. Molecules, 19(7), 9736-9759. https://doi.org/10.3390/molecules19079736

Journal Article Type Article
Publication Date Jul 8, 2014
Deposit Date Jul 14, 2014
Publicly Available Date Jul 20, 2016
Journal Molecules
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 19
Issue 7
Pages 9736-9759
DOI https://doi.org/10.3390/molecules19079736

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