Non-invasive Brain Stimulation and Auditory Verbal Hallucinations: New Techniques and Future Directions

Moseley, Peter; Alderson-Day, Ben; Ellison, Amanda; Jardri, Renaud; Fernyhough, Charles

doi:10.3389/fnins.2015.00515

Non-invasive Brain Stimulation and Auditory Verbal Hallucinations: New Techniques and Future Directions

Moseley, Peter; Alderson-Day, Ben; Ellison, Amanda; Jardri, Renaud; Fernyhough, Charles

Authors

Peter Moseley

Dr Benjamin Alderson-Day benjamin.alderson-day@durham.ac.uk
Professor

Professor Amanda Ellison amanda.ellison@durham.ac.uk
Professor

Renaud Jardri

Professor Charles Fernyhough c.p.fernyhough@durham.ac.uk
Professor

Abstract

Auditory verbal hallucinations (AVHs) are the experience of hearing a voice in the absence of any speaker. Results from recent attempts to treat AVHs with neurostimulation (rTMS or tDCS) to the left temporoparietal junction have not been conclusive, but suggest that it may be a promising treatment option for some individuals. Some evidence suggests that the therapeutic effect of neurostimulation on AVHs may result from modulation of cortical areas involved in the ability to monitor the source of self-generated information. Here, we provide a brief overview of cognitive models and neurostimulation paradigms associated with treatment of AVHs, and discuss techniques that could be explored in the future to improve the efficacy of treatment, including alternating current and random noise stimulation. Technical issues surrounding the use of neurostimulation as a treatment option are discussed (including methods to localize the targeted cortical area, and the state-dependent effects of brain stimulation), as are issues surrounding the acceptability of neurostimulation for adolescent populations and individuals who experience qualitatively different types of AVH.

Citation

Moseley, P., Alderson-Day, B., Ellison, A., Jardri, R., & Fernyhough, C. (2016). Non-invasive Brain Stimulation and Auditory Verbal Hallucinations: New Techniques and Future Directions. Frontiers in Neuroscience, 9, Article 515. https://doi.org/10.3389/fnins.2015.00515

Journal Article Type	Article
Acceptance Date	Dec 22, 2015
Online Publication Date	Jan 19, 2016
Publication Date	Jan 19, 2016
Deposit Date	Jan 25, 2016
Publicly Available Date	Jan 26, 2016
Journal	Frontiers in Neuroscience
Print ISSN	1662-4548
Electronic ISSN	1662-453X
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	9
Article Number	515
DOI	https://doi.org/10.3389/fnins.2015.00515
Keywords	Hallucinations, Neurostimulation, Neuronavigation, State dependency, Transcranial random noise stimulation (tRNS), Transcranial direct current stimulation (tDCS), Transcranial alternating current stimulation (tACS), Transcranial magnetic stimulation (TMS)
Public URL	https://durham-repository.worktribe.com/output/1421942

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Copyright Statement
© 2016 Moseley, Alderson-Day, Ellison, Jardri and Fernyhough. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.