Furosemide Cocrystals: Structures, Hydrogen Bonding, and Implications for Properties

Harriss, Bethany I.; Vella-Zarb, Liana; Wilson, Claire; Radosavljevic Evans, Ivana

Abstract

Four new crystal structures of pharmaceutical molecule furosemide with GRAS coformers are reported and correlated with the known pharmacologically relevant properties of these materials. Furosemide carboxylic acid oxygen donor−coformer aromatic nitrogen acceptor is the dominant synthon, leading to the key intermolecular interactions in the cocrystals studied.

Citation

Harriss, B. I., Vella-Zarb, L., Wilson, C., & Radosavljevic Evans, I. (2014). Furosemide Cocrystals: Structures, Hydrogen Bonding, and Implications for Properties. Crystal Growth and Design, 14(2), 783-791. https://doi.org/10.1021/cg401662d

• Journal Article Type: Article
• Publication Date: Feb 5, 2014
• Deposit Date: Oct 21, 2014
• Publicly Available Date: Jan 28, 2015
• Journal: Crystal Growth and Design
• Print ISSN: 1528-7483
• Electronic ISSN: 1528-7505
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 2
• Pages: 783-791
• DOI: https://doi.org/10.1021/cg401662d
• Public URL: https://durham-repository.worktribe.com/output/1421398