Skip to main content

Research Repository

Advanced Search

Are topical insect repellents effective against malaria in endemic populations? A systematic review and meta-analysis

Wilson, A.L.; Chen-Hussey, V.; Logan, J.G.; Lindsay, S.W.

Are topical insect repellents effective against malaria in endemic populations? A systematic review and meta-analysis Thumbnail


A.L. Wilson

V. Chen-Hussey

J.G. Logan


Background: Recommended vector control tools against malaria, such as long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), mainly target mosquitoes that rest and feed on human hosts indoors. However, in some malaria-endemic areas, such as Southeast Asia and South America, malaria vectors primarily bite outdoors meaning that LLINs and IRS may be less effective. In these situations the use of topical insect repellents may reduce outdoor biting and morbidity from malaria. A systematic review and meta-analysis was conducted to assess the efficacy of topical insect repellents against malaria. Methods: Studies were identified using database searches (MEDLINE, EMBASE, Web of Science and clinical trials registers), as well as reference list searches and contact with researchers. Randomized and non-randomized controlled trials were included that assessed the effect of topical repellents (all active ingredients and concentrations) on Plasmodium falciparum or Plasmodium vivax malaria or infection in malaria-endemic populations. Meta-analysis of clinical data was conducted in order to generate summary risk ratios. Results: Ten trials met the inclusion criteria. Studies varied in terms of repellent active ingredient and formulation, co-interventions, study population, compliance, and follow-up period. Topical repellents showed an 18% protective efficacy against P. falciparum malaria, although this was not significant (95% CI: -8%, 38%). Similarly, the average protective efficacy of topical repellents against P. vivax malaria did not reach significance (protective efficacy: 20%, 95% CI: -37%, 53%). Exclusion of non-randomized trials from the meta-analysis did not alter the findings. Conclusions: Although topical repellents can provide individual protection against mosquitoes, the results of this meta-analysis indicate that topical repellents are unlikely to provide effective protection against malaria. However, there was substantial heterogeneity between studies included and the relatively small number of studies meant that this heterogeneity could not be fully explored in the analysis. Further well-designed trials of topical repellents at appropriate doses and alternative modes of repellent delivery, such as spatial repellents and long-lasting insecticide-treated clothing, are required.


Wilson, A., Chen-Hussey, V., Logan, J., & Lindsay, S. (2014). Are topical insect repellents effective against malaria in endemic populations? A systematic review and meta-analysis. Malaria Journal, 13(1), Article 446.

Journal Article Type Article
Acceptance Date Oct 27, 2014
Online Publication Date Nov 21, 2014
Publication Date Nov 21, 2014
Deposit Date Nov 21, 2014
Publicly Available Date Jan 23, 2015
Journal Malaria Journal
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 13
Issue 1
Article Number 446


Published Journal Article (532 Kb)

Publisher Licence URL

Copyright Statement
© 2014 Wilson et al.; licensee BioMed Central Ltd. <br /> This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

You might also like

Downloadable Citations