Pharmaceutical crystallization with nanocellulose organogels

Ruiz-Palomero, Celia; Kennedy, Stuart R.; Soriano, M. Laura; Jones, Christopher D.; Valcárcel, Miguel; Steed, Jonathan W.

Abstract

Carboxylated nanocellulose forms organogels at 0.3 wt% in the presence of a cationic surfactant. The resulting gels can be used as novel crystallization media for pharmaceutical solid form control, resulting in isolation a new sulfapyridine solvate, morphology modification and crystallization of an octadecylammonium salt of sulfamethoxazole.

Citation

Ruiz-Palomero, C., Kennedy, S. R., Soriano, M. L., Jones, C. D., Valcárcel, M., & Steed, J. W. (2016). Pharmaceutical crystallization with nanocellulose organogels. Chemical Communications, 52(50), 7782-7785. https://doi.org/10.1039/c6cc03088b

• Journal Article Type: Article
• Acceptance Date: May 6, 2016
• Online Publication Date: May 6, 2016
• Publication Date: Jun 25, 2016
• Deposit Date: May 12, 2016
• Publicly Available Date: May 12, 2016
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 50
• Pages: 7782-7785
• DOI: https://doi.org/10.1039/c6cc03088b
• Public URL: https://durham-repository.worktribe.com/output/1412574