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A procedure for the preparation and isolation of nucleoside-5’-diphosphates

Korhonen, H.J.; Bolt, H.L.; Hodgson, D.R.W.

A procedure for the preparation and isolation of nucleoside-5’-diphosphates Thumbnail


Authors

H.J. Korhonen

H.L. Bolt



Abstract

Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5’-diphosphates from crude reaction mixtures.

Citation

Korhonen, H., Bolt, H., & Hodgson, D. (2015). A procedure for the preparation and isolation of nucleoside-5’-diphosphates. Beilstein Journal of Organic Chemistry, 11, 469-472. https://doi.org/10.3762/bjoc.11.52

Journal Article Type Article
Acceptance Date Mar 25, 2015
Publication Date Apr 10, 2015
Deposit Date Apr 8, 2015
Publicly Available Date Apr 14, 2015
Journal Beilstein Journal of Organic Chemistry
Print ISSN 1860-5397
Publisher Beilstein-Institut
Peer Reviewed Peer Reviewed
Volume 11
Pages 469-472
DOI https://doi.org/10.3762/bjoc.11.52
Keywords NDP synthesis, Nucleic acids, Nucleoside-5’-diphosphate, Phosphorylation.

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2015 Korhonen et al; licensee Beilstein-Institut.<br /> This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.







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