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Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2

Guerrini, Irene; Cook, Christopher C.H.; Kest, Wendy; Devitgh, Audrey; McQuillin, Andrew; Curtis, David; Gurling, Hugh M.D.

Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2 Thumbnail


Authors

Irene Guerrini

Wendy Kest

Audrey Devitgh

Andrew McQuillin

David Curtis

Hugh M.D. Gurling



Abstract

Background: In order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study. Methods: DNA from eighteen families, densely affected by alcoholism, was used to genotype a set of polymorphic microsatellite markers at loci approximately 10 centimorgans apart spanning the short arm and part of the long arm of chromosome 1. Linkage analyses were performed using the classical lod score and a model-free method. Three different definitions of affection status were defined, these were 1. Heavy Drinking (HD) where affected subjects drank more than the Royal College of Psychiatrists recommended weekly amount. 2. The Research Diagnostic Criteria for alcoholism (RDCA) 3. Alcohol Dependence Syndrome (ADS) as defined by Edwards and Gross (1976) and now incorporated into ICD10 and DSMIV. Results: Linkage analyses with the markers D1S1588, D1S2134, D1S1675 covering the cytogenetic region 1p22.1-11.2 all gave positive two point and multipoint lods with a maximum lod of 1.8 at D1S1588 (1p22.1) for the RDCA definition of alcoholism. Another lod of 1.8 was found with D1S1653 in the region 1q21.3-24.2 using the HD affection model. Conclusion: These results both support the presence of linkage in the 1p22.1-11.2 region which was previously implicated by the USA Collaborative Study of the Genetics of Alcoholism (COGA) study and also suggest the presence of another susceptibility locus at 1q21.3-24.2.

Citation

Guerrini, I., Cook, C. C., Kest, W., Devitgh, A., McQuillin, A., Curtis, D., & Gurling, H. M. (2005). Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2. BMC Genetics, 6, Article 11. https://doi.org/10.1186/1471-2156-6-11

Journal Article Type Article
Publication Date Mar 1, 2005
Deposit Date Jun 26, 2015
Publicly Available Date Aug 26, 2015
Journal BMC Genetics
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 6
Article Number 11
DOI https://doi.org/10.1186/1471-2156-6-11

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Copyright Statement
© 2005 Guerrini et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.





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