Evidence-based vector control? Improving the quality of vector control trials

Wilson, A.L.; Boelaert, M.; Kleinschmidt, I.; Pinder, M.; Scott, T.W.; Tusting, L.S.; Lindsay, S.W.

Abstract

Vector-borne diseases (VBDs) such as malaria, dengue, and leishmaniasis cause a high level of morbidity and mortality. Although vector control tools can play a major role in controlling and eliminating these diseases, in many cases the evidence base for assessing the efficacy of vector control interventions is limited or not available. Studies assessing the efficacy of vector control interventions are often poorly conducted, which limits the return on investment of research funding. Here we outline the principal design features of Phase III vector control field studies, highlight major failings and strengths of published studies, and provide guidance on improving the design and conduct of vector control studies. We hope that this critical assessment will increase the impetus for more carefully considered and rigorous design of vector control studies.

Citation

Wilson, A., Boelaert, M., Kleinschmidt, I., Pinder, M., Scott, T., Tusting, L., & Lindsay, S. (2015). Evidence-based vector control? Improving the quality of vector control trials. Trends in Parasitology, 31(8), 380-390. https://doi.org/10.1016/j.pt.2015.04.015

• Journal Article Type: Article
• Online Publication Date: May 19, 2015
• Publication Date: Aug 1, 2015
• Deposit Date: May 20, 2015
• Publicly Available Date: May 26, 2015
• Journal: Trends in Parasitology
• Print ISSN: 1471-4922
• Electronic ISSN: 1471-5007
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 8
• Pages: 380-390
• DOI: https://doi.org/10.1016/j.pt.2015.04.015
• Keywords: Vector-borne disease, Vector control, Phase III trials, Research design / standards.
• Public URL: https://durham-repository.worktribe.com/output/1405124