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Histamine in diabetes: is it time to reconsider?

Pini, A.; Obara, I.; Battell, E.; Chazot, P.L.; Rosa, A.C.

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A. Pini

I. Obara

E. Battell

A.C. Rosa


The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an increase in plasma and leucocyte histamine content was observed. Limited independent evidence followed in the subsequent two decades, focusing on both histamine glyceamic control and macro- and microvascular complications of diabetes. However, recent observations have sparked the question whether it is time to reconsider the functional contribution of histamine in diabetes. We reveal an interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes.


Pini, A., Obara, I., Battell, E., Chazot, P., & Rosa, A. (2016). Histamine in diabetes: is it time to reconsider?. Pharmacological Research, 111, 316-324.

Journal Article Type Article
Acceptance Date Jun 21, 2016
Online Publication Date Jun 22, 2016
Publication Date Sep 1, 2016
Deposit Date Jul 4, 2016
Publicly Available Date Jun 22, 2017
Journal Pharmacological Research
Print ISSN 1043-6618
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 111
Pages 316-324


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