The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient

Forssell-Aronsson, E.; Quinlan, R.A.

Abstract

Daily rhythmic changes are found in cellular events in cell cycle, DNA repair, apoptosis and angiogenesis in both normal and tumour tissue, as well as in enzymatic activity and drug metabolism. In this paper, we hypothesize that circadian rhythms need to be considered in radiation protection and optimization in personalized medicine, especially for paediatric care. The sensitivity of the eye lens to ionizing radiation makes the case for limiting damage to the lens epithelium by planning medical radio-imaging procedures for the afternoon, rather than the morning. Equally, the tumour and normal tissue response to radiotherapy is also subject to diurnal variation enabling optimization of time of treatment.

Citation

Forssell-Aronsson, E., & Quinlan, R. (2017). The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient. Radiation Protection Dosimetry, 173(1-3), 16-20. https://doi.org/10.1093/rpd/ncw328

• Journal Article Type: Article
• Acceptance Date: Oct 28, 2016
• Online Publication Date: Nov 15, 2016
• Publication Date: Apr 1, 2017
• Deposit Date: Nov 14, 2016
• Publicly Available Date: Nov 15, 2017
• Journal: Radiation Protection Dosimetry
• Print ISSN: 0144-8420
• Electronic ISSN: 1742-3406
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 173
• Issue: 1-3
• Pages: 16-20
• DOI: https://doi.org/10.1093/rpd/ncw328
• Public URL: https://durham-repository.worktribe.com/output/1400850