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Shape Transformations of Lipid Bilayers Following Rapid Cholesterol Uptake

Rahimi, M.; Regan, D.; Arroyo, M.; Subramaniam, A.B.; Stone, H.A.; Staykova, M.

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Authors

M. Rahimi

D. Regan

M. Arroyo

A.B. Subramaniam

H.A. Stone



Abstract

High cholesterol levels in the blood increase the risk of atherosclerosis. A common explanation is that the cholesterol increase in the plasma membrane perturbs the shape and functions of cells by disrupting the cell signaling pathways and the formation of membrane rafts. In this work, we show that after enhanced transient uptake of cholesterol, mono-component lipid bilayers change their shape similarly to cell membranes in vivo. The bilayers either expel lipid protrusions or spread laterally as a result of the ensuing changes in their lipid density, the mechanical constraints imposed on them, and the properties of cyclodextrin used as a cholesterol donor. In light of the increasingly recognized link between membrane tension and cell behavior, we propose that the physical adaptation of the plasma membrane to cholesterol uptake may play a substantial role in the biological response.

Citation

Rahimi, M., Regan, D., Arroyo, M., Subramaniam, A., Stone, H., & Staykova, M. (2016). Shape Transformations of Lipid Bilayers Following Rapid Cholesterol Uptake. Biophysical Journal, 111(12), 2651-2657. https://doi.org/10.1016/j.bpj.2016.11.016

Journal Article Type Article
Acceptance Date Nov 3, 2016
Online Publication Date Dec 20, 2016
Publication Date Dec 20, 2016
Deposit Date Jan 6, 2017
Publicly Available Date Dec 20, 2017
Journal Biophysical Journal
Print ISSN 0006-3495
Publisher Biophysical Society
Peer Reviewed Peer Reviewed
Volume 111
Issue 12
Pages 2651-2657
DOI https://doi.org/10.1016/j.bpj.2016.11.016
Public URL https://durham-repository.worktribe.com/output/1389179

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