Insidious pathogen-mimicking properties of nanoparticles in triggering the lectin pathway of the complement system

Moghimi, S.M.; Wibroe, P.P.; Wu, L.; Farhangrazi, Z.S.

Abstract

The lectin pathway of the complement system is an integral component of the innate immune system recognizing pathogens through patterns of sugar moieties displayed on their surfaces and neutralizing them through an antibody-independent reaction cascade. Many engineered nanoparticles incite complement through the lectin pathway, but these nanoparticles inherently do not express surface-exposed sugars. However, the projected polymeric surface architecture of nanoparticles may transiently resemble structural motifs of peptidoglycan constituents of pathogens and trigger the lectin pathway. We discuss these issues in relation to nanomedicine design and immune safety.

Citation

Moghimi, S., Wibroe, P., Wu, L., & Farhangrazi, Z. (2015). Insidious pathogen-mimicking properties of nanoparticles in triggering the lectin pathway of the complement system. European Journal of Nanomedicine, 7(3), 263-268. https://doi.org/10.1515/ejnm-2015-0014

• Journal Article Type: Article
• Acceptance Date: Mar 26, 2015
• Online Publication Date: Apr 29, 2015
• Publication Date: Jun 1, 2015
• Deposit Date: Apr 18, 2016
• Publicly Available Date: Jun 21, 2016
• Journal: European Journal of Nanomedicine
• Electronic ISSN: 1662-596X
• Publisher: De Gruyter
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 3
• Pages: 263-268
• DOI: https://doi.org/10.1515/ejnm-2015-0014
• Public URL: https://durham-repository.worktribe.com/output/1386567