Heavy Chain Only Antibodies: A New Paradigm in Personalized HER2+ Breast Cancer Therapy

Moghimi, S.M.; Rahbarizadeh, F.; Ahmadvand, D.; Parhamifar, L.

Abstract

Unlike conventional antibodies, heavy chain only antibodies derived from camel contain a single variable domain (VHH) and two constant domains (CH2 and CH3). Cloned and isolated VHHs possess unique properties that enable them to excel conventional therapeutic antibodies and their smaller antigen-binding fragments in cancer targeting and therapy. VHHs express low immunogenicity, are highly robust and easy to manufacture and have the ability to recognize hidden or uncommon epitopes. We highlight the utility of VHH in design of new molecular, multifunctional particulate and immune cell-based systems for combating HER2+ breast cancer.

Citation

Moghimi, S., Rahbarizadeh, F., Ahmadvand, D., & Parhamifar, L. (2013). Heavy Chain Only Antibodies: A New Paradigm in Personalized HER2+ Breast Cancer Therapy. BioImpacts, 3(1), 1-4. https://doi.org/10.5681/bi.2013.009

• Journal Article Type: Article
• Acceptance Date: Jan 25, 2013
• Online Publication Date: Jan 27, 2013
• Publication Date: Jan 27, 2013
• Deposit Date: Apr 18, 2016
• Publicly Available Date: Dec 14, 2017
• Journal: Bioimpacts
• Electronic ISSN: 2228-5660
• Publisher: Tabriz University of Medical Sciences
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 1
• Pages: 1-4
• DOI: https://doi.org/10.5681/bi.2013.009
• Public URL: https://durham-repository.worktribe.com/output/1414371