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Repurposing as a Strategy for the Discovery of New Anti-Leishmanials: The-State-of-the-Art

Charlton, Rebecca; Rossi-Bergmann, Bartira; Denny, Paul W.; Steel, Patrick G.

Repurposing as a Strategy for the Discovery of New Anti-Leishmanials: The-State-of-the-Art Thumbnail


Authors

Rebecca Charlton

Bartira Rossi-Bergmann



Abstract

Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs. There are 1·3 million new cases each year causing considerable socio-economic hardship, best measured in 2·4 million disability adjusted life years, with greatest impact on the poorest communities, which means that desperately needed new antileishmanial treatments have to be both affordable and accessible. Established medicines with cheaper and faster development times may hold the cure for this neglected tropical disease. This concept of using old drugs for new diseases may not be novel but, with the ambitious target of controlling or eradicating tropical diseases by 2020, this strategy is still an important one. In this review, we will explore the current state-of-the-art of drug repurposing strategies in the search for new treatments for leishmaniasis.

Citation

Charlton, R., Rossi-Bergmann, B., Denny, P. W., & Steel, P. G. (2018). Repurposing as a Strategy for the Discovery of New Anti-Leishmanials: The-State-of-the-Art. Parasitology, 145(2), 219-236. https://doi.org/10.1017/s0031182017000993

Journal Article Type Article
Acceptance Date May 25, 2017
Online Publication Date Aug 14, 2017
Publication Date Feb 1, 2018
Deposit Date May 25, 2017
Publicly Available Date Aug 22, 2017
Journal Parasitology
Print ISSN 0031-1820
Electronic ISSN 1469-8161
Publisher Cambridge University Press
Peer Reviewed Peer Reviewed
Volume 145
Issue 2
Pages 219-236
DOI https://doi.org/10.1017/s0031182017000993
Public URL https://durham-repository.worktribe.com/output/1386253

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Advance online version © Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the
CreativeCommons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution,
and reproduction in any medium, provided the original work is properly cited.






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