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Development of the industrial synthesis of vitamin A

Parker, G.L.; Smith, L.K.; Baxendale, I.R.


G.L. Parker

L.K. Smith


The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems. Arens and van Dorp published the first route in 1946, and critical contributions have been made by a number of scientists since, benefitting from fruitful collaborations between industry and academia. However, these improvements have been mostly incremental, and the work has been performed by a limited number of companies; as yet, there is still no ‘ideal’ synthesis of vitamin A.


Parker, G., Smith, L., & Baxendale, I. (2016). Development of the industrial synthesis of vitamin A. Tetrahedron, 72(13), 1645-1652.

Journal Article Type Article
Acceptance Date Feb 10, 2016
Online Publication Date Feb 11, 2016
Publication Date 2016-03
Deposit Date Mar 22, 2016
Journal Tetrahedron
Print ISSN 0040-4020
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 72
Issue 13
Pages 1645-1652
Public URL